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Lecture 3 - Toxicology Concepts

Learning Objectives

  1. Define toxicity.
  2. Discuss different types of toxic responses.
  3. Explain how toxicants are classified.
  4. Describe the phases of toxicosis.
  5. Explain how concomitant exposure influences toxicity.
  6. Develop an introductory understanding of toxicity testing.

LECTURE MATERIALS

Slides

PDF Notes

LECTURE ACTIVITIES

Homework

Discussion

eTOX Lecture03 from Professor Greg Möller on Vimeo.

Listen online or Download here

Advance Reading

  1. Richards 2nd ed., pp 51-60
  2. NLM Toxicology Tutor
    3.

Resources

Keywords

  • Absorption
  • Acute toxicity
  • Biotransformation
  • Chronic toxicity
  • Delayed toxicity
  • Distribution
  • Excretion, elimination
  • End effect
  • Immediate toxicity
  • in vitro
  • in vivo
  • Linear dose sequence
  • Local toxicity
  • Logarithmic dose sequence
  • Storage
  • Systemic toxicity
  • Toxicity testing
  • Toxicodynamics
  • Toxicokinetics

Suggested Reading

  1. Foundation for Biomedical Research
  2. Alternatives to Animal Testing
  3. Americans for Medical Progress Foundation
  4. People for the Ethical Treatment of Animals

Suggested Exercise

  1. Go to the Protein Data Bank (PDB) site and view human fetal Hemoglobin and bar-headed goose Hemoglobin. You may have to download one of the 3-D viewing support tools. PDB is the single worldwide repository for the processing and distribution of 3-D biological macromolecular structure data.
  2. Use the structure screen tools and your mouse to explore the inner working and structure of this complex compound.
  3. What do you notice about the "active site" in both molecules?


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