Lecture 8 - Biotransformation
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Learning Objectives
- Explain the role of biotransformation in toxicokinetics.
- Describe how biotransformation facilitates the elimination of toxicants or their metabolites from the body.
- Distinguish between Phase I and Phase II biotransformation reactions.
- Define bioactivation or toxication.
- dentify the tissues responsible for biotransformation reactions.
- List the factors affecting biotransformation in humans.
- Summarize the role of elimination in toxicokinetics.
- Describe processes occurring in the kidney, liver, and lung as related to the elimination of toxicants.