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Lecture 7 - Distribution and Storage of Toxicants

Learning Objectives

  1. Identify the ways toxicants are distributed in the body.
  2. Recognize the relationship between route of absorption and pathway for distribution.
  3. Describe factors affecting distribution.
  4. Define volume of distribution.
  5. List storage sites.
  6. Discuss how storage influences toxicant half-life.
  7. Review case studies and model of storage and distribution.
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Advance Reading

  1. Hughes, pp 60-68
  2. Shibamoto & Bjeldanes, pp 20-26
  3. NLM Toxicology Tutor Distribution
  4. Enterohepatic Recirculation Animation
  5. Download, install, and survey IEUBK and LEADSPREAD computer models for blood lead.

Suggested Reading

  1. IEUBK background documents

Resources

Keywords

  • Adipose tissues
  • Albumin
  • Arterial vessels
  • Blood flow
  • Blood flow/ mass ratio
  • Blood plasma
  • Blood-brain barrier
  • Capillaries
  • Cardiac output
  • Distribution
  • Erythrocytes
  • Heart
  • Interstitial fluid
  • Intracellular fluid
  • Leukocytes
  • Lymph
  • Lymph capillaries
  • Lymph nodes
  • Lymphatic system
  • Lymphocytes
  • Lymphoid tissue
  • Placental barrier
  • Plasma protein
  • Platelets
  • Portal vein
  • Storage
  • Venous vessels
  • Volume of distribution (VD)