Patrick J. Hrdlicka
PO Box 442343
Renfrew Hall 313W
Moscow, Idaho 83844-2343
United States of America
Phone: +1 208-885-0108
Fax: +1 208-885-6173
Publication (2013) - Our manuscript entitled "Identification and Characterization of Second-Generation Invader Locked Nucleic Acids (LNAs) for Mixed-Sequence Recognition of Double-Stranded DNA", has been published in The Journal of Organic Chemistry as a Featured Article.
Publication (2013) - Our manuscript entitled "Sandwich assay for mixed-sequence recognition of double-stranded DNA: Invader-based detection of targets specific to foodborne pathogens", has been published in Chem. Commun.
Alumni success (2013) - Dale and Dr. Hrdlicka have written this little piece for The Oligonucleotide Therapeutics Society about a recent study from industry leader Isis Pharmaceuticals. The lead author on that study, Michael Østergaard, was the first Ph.D.-student to graduate from the Hrdlicka lab.
Funding (2013) - Dr. Hrdlicka receives another 1-yr grant from the Idaho State Board of Education for the development of diagnostic kits that are based on our proprietary Invader Technology.
Publication (2013) - Our manuscript entitled "Invaders: Recognition of Double-Stranded DNA using Duplexes Modified with Interstrand Zippers of 2'-O-(Pyren-1-yl)methylribonucleotides", has been published in ChemBioChem. In this proof-of-concept paper, we demonstrate that Invaders enable mixed-sequence recognition of DNA hairpins in cell free assays, and of chromosomal DNA under non-denaturing conditions.
Guest Editor (2013) - Dr. Hrdlicka serves as the guest editor on the special issue of Chemosensors entitled "Nucleic Acid Probes".
Publication (2013) - Saswata's article entitled "DNA Strands with Alternating Incorporations of LNA and 2'-O-(pyren-1-yl)methyluridine: SNP-discriminating RNA Detection Probes", has been published in Chemical Science.
Award (2013) - Dr. Hrdlicka receives the Excellence in Research and Creative Activity Award from the University of Idaho.
New laboratory (2013) - Our BSL1-level laboratory, which is fully equipped for mammalian cell culture studies and molecular biological experiments, is open for business! Thank you to Prof. Larry Branen (Univ. Idaho) for a very genrous equipment donation, and to Dale Guenther for handling set-up and paperwork.
Student news (2013) - Saswata will be joining Prof. Eric Kool's lab at Stanford as a postdoctoral fellow upon completion of his studies. Congrats !
Student news (2013) - Undergraduate researchers Max Cowan and Phil Vukelich have joined the group - welcome !!!
Bibliographic highlight (2013) - Our work has been cited >650 times across 340 different articles.
Publication (2012) - Mamta's article entitled "Synthesis and hybridization properties of oligonucleotides modified with 5-(1-aryl-1,2,3-triazol-4-yl)-2′-deoxyuridines", has been published in Organic and Biomolecular Chemistry as a 'hot communication'.
Funding (2012) - Dr. Hrdlicka has received a 1-yr grant from the Idaho State Board of Education for the development of diagnostic kits that are based on our proprietary Invader Technology.
Award (2012) - Dr. Hrdlicka receives the President’s inaugural Mid-career Faculty Award from the University of Idaho.
Publication (2012) - Sujay's paper entitled "C2'-Pyrene-functionalized triazole-linked DNA: Universal DNA/RNA hybridization probes", has been published in the Journal of Organic Chemistry as a Cover Article.