Jack Sullivan 

Updated Spring 2023

Biology 545 - Phylogenetics

Syllabus

Readings for alternate Mondays

Link to Zoom Lectures

Lecture Notes & Slides

Lecture 1 - Introduction to Systematics and Phylogenetics. Notes Slides.

Costello et al. (2013). An estimate of current diversity (that focuses on macrobial species).

Locey & Lennon (2016). An estimate of the number of extant microbial species.

Lecture 2 - The History of Phylogenetic Inference. Notes Slides.

Quinn (2017). An interesting take on the evolution of the term "cladist."

Lecture 3 - Characters: Morphology & Homology. Notes Slides.

Lecture 4 - Characters: Molecular. Notes Slides.

Lecture 5 - Sequence Alignment. Notes Slides.

Lecture 6A - Introduction to Trees and Optimality Criteria: Parsimony. Notes Slides.

Lecture 6B - Optimality Criteria: Maximum Likelihood and Minimum Evolution. Notes Slides.

Lecture 7 - Algorithmic Tree-Building Approaches. Notes Slides.

Lecture 8 - Searching Tree Space. Notes Slides.

Lecture 9 - The Importance of Models. Notes Slides.

Lecture 10 - Models of Sequence Evolution. Notes Slides.

Lecture 11 - Increasing Model Complexity. Notes Slides.

Lecture 12 - Model Selection. Notes Slides.

Lecture 13 - Consensus Trees and Nodal Support. Notes Slides.

Lecture 14 - Perfromance of Methods. Notes Slides.

Lecture 15 - Hypothesis Testing. Notes Slides.

Lecture 16 - Molecular Clocks. Notes Slides.

Lecture 17 - Partitioned Models and Mixture Models. Notes Slides.

Lecture 18 - Species-tree Estimation. Notes Slides.

Lecture 19 - Phylogenetic Networks. Notes Slides.

Links to Recorded Lectures

Thursday, 1/12.

Tuesday, 1/17.

Tuesday, 1/24.

Thursday, 1/26.

Tuesday, 1/31.

Thursday, 2/2.

Tuesday, 2/7.

Thursday, 2/9.

Tuesday, 2/14.

Thursday, 2/16.

Tuesday, 2/21.

Tuesday, 2/28.

Thursday, 3/2.

Tuesday, 3/7.

Thursday, 3/9.

Tuesday, 3/21.

Thursday, 3/23.

Tuesday, 3/28.

Thursday, 3/30.

Tuesday, 4/4.

Thursday, 4/6.

Tuesday, 4/11.

Tuesday, 4/18.

Thursday, 4/20.

Tuesday, 4/25.

Thursday, 4/27.

Labs

Lab 1 - Alignment.

Lab 2 - Tree Searching and Parsimony.

Data Set.

Lab 3 - Model-based Methods.

Data Set.

Lab 4 - Nodal Support.

Lab 5 - Species-Tree Estimation.

Targeted Capture Data.

File that maps individuals to species.

RAxML trees for each syntenic group.

Problem Sets

Problem Set 1 Answers.

Problem Set 2 Answers.

Old Exams

Old Exam 1.

Old Exam 2.