This program is associated
with De Gelder et.al.
(2004), and Ponciano et.al. (2007), wherein a mathematical model is
introduced that aims to explain
the evolutionary process of the loss of the tetracycline resistance
operon from a plasmid contained in E. coli. This model is coupled with
a statistical framework based on the maximum likelihood to estimate its
parameters and to test the associated hypotheses.
written in R. R is a language
and environment for
statistical computing and graphics. Download R and
read and follow the instructions in the Manual,
running these two programs.
text file with the data from De Gelder et.al. 2004 by clicking (here) . This data is used as an
example in the Manual
If you have implemented the program
correctly you should get the same
results as in the paper.