Lecture 5 - Dose-Response Relationships
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Learning Objectives
- Understand the quantitative relationship between toxicant exposure and induced effect.
- Describe frequently encountered toxic effects.
- Understand threshold effects with dosage increase.
- Understand effective dose, margin of safety and the relationship of effective vs. toxic dose.
- Examine the use of actual data for no observed effect and lowest observed effect in risk assessments.
- Summarize effective, lethal and toxic doses.
- Understand a linearized, multi-stage model for non-threshold responses.