Lecture 7 - Distribution and Storage of Toxicants
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Learning Objectives
- Identify the way toxicants are distributed by the body.
- Recognize the relationship between a specific route of absorption and the related pathways for distribution of a toxicant.
- Describe the factors affecting distribution of toxicants to tissues.
- Define volume of distribution.
- List the sites for toxicant storage.
- Discuss how storage influences toxicant half-life.
- Perform an LD50 experiment.
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Advance Reading
- Richards 2nd ed., pp 145-151
- NLM Toxicology Tutor Distribution
- Case Study: Aldicarb in Watermelons
- IEUBK
Resources
Keywords
- Adipose tissues
- Albumin
- Arterial vessels
- Blood flow
- Blood flow/ mass ratio
- Blood plasma
- Blood-brain barrier
- Capillaries
- Cardiac output
- Distribution
- Erythrocytes
- Heart
- Interstitial fluid
- Intracellular fluid
- Leukocytes
- Lymph
- Lymph capillaries
- Lymph nodes
- Lymphatic system
- Lymphocytes
- Lymphoid tissue
- Placental barrier
- Plasma protein
- Platelets
- Portal vein
- Storage
- Venous vessels
- Volume of distribution (VD)
Suggested Reading
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