Lecture 9 - Target Organ Toxicity
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Learning Objectives
- Define target organ toxicity.
- Explain the basis for the specificity of organ toxicity.
- Contrast the toxicity mechanisms for hematotoxicity, hepatotoxicity, nephrotoxicity, neurotoxicity, dermatotoxicity, and pulmonotoxicity.
- Describe examples of target organ toxicity.
- Discuss the characteristic evaluative procedures for determining toxicity in target organs.
- Explain the concept of oxidative stress and demonstrate an understanding of the action of antioxidant enzymes and redox cycling compounds.
- Examine the molecular pathways of cholinesterase inhibition.