Lecture 5 - Dose-Response Relationships

Learning Objectives

1. Understand the quantitative relationship between toxicant exposure and induced effects.
2. Describe frequently encountered toxic effects.
3. Interpret frequency (normal distribution) and dose - response curves.
4. Understand threshold effects with dosage increase.
5. Understand effective dose, margin-of-safety and the relationship of effective vs. toxic dose.
6. Examine the use of actual data for no observed effect and lowest observed effect in risk assessments.
7. Summarize effective, lethal and toxic doses.
8. Understand a linearized multi-stage model for non-threshold responses.