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Lecture 10 - Teratogenesis, Mutagenesis and Carcinogenesis

Learning Objectives

  1. Define teratogenesis, mutagenesis, and carcinogenesis.
  2. Describe the relevance of replication, transcription, and translation to teratogenesis, mutagenesis, and carcinogenesis.
  3. Summarize the mechanism of action for teratogens, mutagens,  and carcinogens.
  4. Discuss examples of known teratogens, mutagens, and carcinogens.
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Advance Reading

  1. Hughes, pp 107-122
  2. NLM Toxicology Tutor, Cancer
  3. Shibamoto & Bjeldanes, pp 85-95

Suggested Reading

  1. Learn About Cancer-American Cancer Society
  2. Shibamoto & Bjeldanes, pp 95-97

Resources

Keywords

  • Agenesis
  • Ames assay
  • Aneuploidy
  • Anticodons
  • Atresia
  • Base analogues
  • Base substitution
  • Cancer
  • Carcinogenesis
  • Carcinogens
  • Cellular division
  • Centromere
  • Chromosome
  • Codon
  • Deoxyribonucleic acid (dna)
  • Developmental syndromes
  • Diploid
  • Division failures
  • Dysraphic anomalies
  • Ectopia
  • Embryogenesis
  • Embryolethality
  • Epigenetic
  • Fetal alcohol syndrome
  • Frameshift
  • Gene
  • Genetic code
  • Genotoxic
  • Germ cells
  • Haploid
  • Histogenesis
  • Hypoplasia
  • Initiation
  • Karyotype
  • Meiosis
  • Metaphase
  • Mitosis
  • Monosomy
  • Morphogenesis
  • Mutagenesis
  • Mutagens
  • Nucleic acids
  • Nucleotides
  • Oogenesis
  • Organogenesis
  • Point mutation
  • Polyploidy
  • Procarcinogen
  • Promotion
  • Purines
  • Pyrimidines
  • Replication
  • Ribonucleic acid
  • Somatic cells
  • Spermatogenesis
  • Teratogenesis
  • Teratogens
  • Teratology
  • Transcription
  • Translation
  • Trisomy