Lecture 8 - Biotransformation and Elimination of Toxicants
Learning Objectives
- Explain the role of biotransformation in toxicokinetics.
- Describe how biotransformation facilitates elimination of toxicants.
- Distinguish between Phase I and Phase II reactions.
- Define bioactivation or toxication
- Identify tissues and factors involved in biotransformation.
- Summarize the role of elimination in toxicokinetics.
- Describe processes occurring in the kidney, liver and lung related to the elimination of toxicants.
Listen online or Download audio LecturesDownload audio Lectures
Advance Reading
- Shibamoto & Bjeldanes, pp 53-81; 27-31
- Hughes, pp 72-82
- NLM Toxicology Tutor Biotransformation and Excretion
Suggested Reading
- Liver Disease Information Center - American Liver Foundation
Resources
Keywords
- Anabolism
- Bioactivation
- Biological half-life (t1/2)
- Biotransformation
- Catabolism
- Conjugate
- Conjugation reactions
- Cytochrome p-450
- Cytosolic enzymes
- Detoxication
- Enterohepatic loop
- Fecal excretion
- Glomerular filtration
- Glucuronidation
- Hydrolysis
- Intestinal excretion
- Ionized molecules
- Metabolism
- Microsomal enzymes
- Nephrons
- Oxidation
- Phase I biotransformation
- Phase II biotransformation
- Reabsorption
- Reduction
- Secretion
- Sulfate conjugation
- Toxication
ETox is licensed under a Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International License.